I have DESIGNED and SYNTHESIZED original and novel chiral molecules based on TEREPHTHALAMIDEs. All these molecules consist of phenylene-ethynylene units, leading to molecular framework robustness and conformational flexibility.
The dynamic features of terephthalamides provide diverse equilibrium in solution (e.g., reversal of helical-sense preferences, enhanced optical activity at elevated temperatures, induction of innate helical-sense preference in a multi-fold twisting).
Recent interest is chirality created in the molecular assembly (multi-layer cyclophanes and interlocked ring and rod) of achiral aromatic hydrocarbons through terephthaloyl bridges.
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