Regulatory mechanism of heat-active retrotransposons by the SET domain protein SUVH2

ITO Hidetaka

Department of Biological Sciences

Feb. 15, 2024

野生型、suvh2変異体、nrpd1変異体におけるONSENの転写量と転移数。RdDM経路の重要な因子であるSUVH2とNRPD1はそれぞれ独立の役割を担っており、SUVH2はONSENの転写制御、NRPD1はsiRNAを介した転移制御を行っている。

Press release (in Japanese)

Abstract
New transposon insertions are deleterious to genome stability.The RNA-directed DNA methylation (RdDM) pathway evolved to regulate transposon activity via DNA methylation.However, current studies have not yet clearly described the transposition regulation. ONSEN is a heat-activated retrotransposon that is activated at 37°C. The plant-specific SUPPRESSOR OF VARIEGATION 3–9 HOMOLOG (SUVH) family proteins function downstream of the RdDM pathway. The SUVH protein families are linked to TE silencing by two pathways, one through DNA methylation and the other through chromatin remodeling. In this study, we analyzed the regulation of….

Read the original article on Frontiers in Plant Science

Article Information:
Niu Xiaoying, Ge Zhiyu, Ito Hidetaka,
Regulatory mechanism of heat-active retrotransposons by the SET domain protein SUVH2
Frontiers in Plant Science, 8 December 2024.
DOI: 10.3389/fpls.2024.1355626