Researcher Information


Specially Appointed Assistant Professor

Elucidating and manipulating organic reactive species

Department of Chemistry, Organic and Biological Chemistry


Development of chemical reactions mediated by organic reactive species based on flow microsynthesis

Fieldorganic synthetic chemistry, organoelectro chemistry, flow chemistry
Keywordreactive species, flow microsynthesis, organoelectro synthesis

Introduction of Research

The research purpose is to develop chemical reactions that cannot be achieved with a conventional macro reactor, by using flow microreactors.

Representative Achievements

Flow grams-per-hour production enabled by hierarchical bimodal porous silica gel supported palladium column reactor having low pressure drop. Ashikari, Y.; Maekawa, K.; Takumi, M.; Tomiyasu, N.; Fujita, C.; Matsuyama, K.; Miyamoto, R.; Bai, H.; Nagaki, A. Catal. Today 2022, 388-389, 231-236.
Switchable Chemoselectivity of Reactive Intermediates Formation and Their Direct Use in a Flow Microreactor. Ashikari, Y.; Tamaki, T.; Kawaguchi, T.; Furusawa, M.; Yonekura, Y.; Ishikawa, S.; Takahashi, Y.; Aizawa, Y.; Nagaki, A. Chem. Eur. J. 2021, 27, 16107-16111.
A Synthetic Approach to Dimetallated Arenes Using Flow Microreactors and the Switchable Application to Chemoselective Cross-Coupling Reactions. Ashikari, Y.; Kawaguchi, T.; Mandai, K.; Aizawa, Y.; Nagaki, A. J. Am. Chem. Soc. 2020, 142, 17039-17047. (Cover Art)
A Novel Approach to Functionalization of Aryl Azides via Generation and Reactions of Organolithiums Bearing Masked Azides Using Flow Microreactors. Ichinari, D.; Ashikari, Y.; Mandai, K.; Aizawa, Y.; Yoshida, J.; Nagaki, A. Angew. Chem. Int. Ed. 2020, 59, 1567-1571.
Oxo-Thiolation of Cationically Polymerizable Alkenes Using Flow Microreactors. Ashikari, Y.; Saito, K.; Nokami, T.; Yoshida, J.; Nagaki, A. Chem. Eur. J. 2019, 25, 15239-15243. (Cover Art)

Related industries

chemistry, pharmaceuticals
Academic degreePh.D
Self Introduction

I am researching everyday looking forward to new chemical discoveries and delicious foods. I am happy sharing excitement with collaborators through our research.

Academic background2008 B.S. Faculty of Engineering, Kyoto University
2010 M. Eng. Graduate School of Engineering, Kyoto University
2013 Ph.D. Graduate School of Engineering, Kyoto University
2013 Postdoctoral fellow, Graduate School of Engineering, Kyoto University
2014 Postdoctoral Fellow, Department of Chemistry, University of Washington
2017 Postdoctoral fellow, Department of Pharmacology, Keio University
2019 Postdoctoral fellow, Graduate School of Engineering, Kyoto University
2022 Postdoctoral fellow, Faculty of Science, Hokkaido University
2022 Specially Appointed Assistant Professor, Faculty of Science, Hokkaido University
Affiliated academic societyThe chemical Society of Japan, The society of Synthetic Organic Chemistry, Japan
Room addressScience Building 7, 7-404