To unravel mysteries in the birth of animals
Department of Biological Sciences, Reproductive and Developmental Biology
To elucidate cellular and mollecular mechanisms of vertebrate oogenesis and embryogenesis
|Field||Cell Biology, Molecular Biology, Developmental Biology, Genetics|
|Keyword||Zebrafish, Mouse, Maternal Factor, Oogeneis, Early Development, Insertional Mutation, Transposon, Meiosis, Mitotic Cleavage, Morphogenesis, Embryonic Axis Formation|
Introduction of Research
Mechanisms by which fertilizable eggs are formed and highly organized individual animals are developed subsequently after fertilization remains largely unknown, although oogenesis and development of many species have been morphologically analyzed. Recent studies demonstrated that tens of thousands of mRNAs are accumulated in vertebrate oocytes. Our goal is to understand cellular and molecular mechanisms of oogenesis and early development of vertebrates by discovering functions of these transcripts deposited in oocytes.
Y. Nukada, M. Horie, A. Fukui, T. Kotani, M. Yamashita.
Cytoskeleton, 2015, vol.72, p491-501.
T. Kotani, K. Yasuda, R. Ota, M. Yamashita. Journal of Cell Biology, 2013, vol.202, p1041-1055.