Researcher Information

Takahiro Suzuki

Associate Professor

Synthesis of Novel Complex Molecule

Department of Chemistry, Organic and Biological Chemistry

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Theme

Total Synthesis of Bioactive Complex Natural Products

FieldOrganic Synthesis, Natural Product Chemistry, Organic Reaction
Keywordtotal synthesis, retrosynthetic analysis, C-C bond formation reaction, cycloaddition reaction, asymmetric catalysis, terpenoids, polyketides, high-pressure organic synthesis, biomimetic synthesis

Introduction of Research

Organic compounds produced from nature have various actions on living organisms, and human beings have used natural compounds as drugs and poisons from ancient times. Since the synthesis of urea by F. Wöhler in the early 19th century, organic chemists were fascinated by the synthesis of naturally derived compounds and have synthesized many natural compounds to date. Natural compounds synthesized by chemists, including their derivatives, have been widely used such as pharmaceuticals and agrichemicals, perfumes, pigments and functional materials, and have made a great contribution to improving the welfare of mankind. Under such circumstances, we are conducting synthetic studies on biologically active natural compounds and have achieved total synthesis of various natural compounds so far.
In order to synthesize these compounds, extensive knowledge on organic chemistry is necessary to control a large number of functional groups, asymmetric centers and fused ring structures. Also, as the chemical structure becomes more complex, it is necessary to develop new reactions and synthesis methods. Through the accumulation of fundamental research in the field of organic chemistry, our synthesis research will be established.
Due to the complexity of its chemical structure, some natural compounds have not yet been synthesized in spite of all efforts by synthetic organic chemists. By targeting such molecules, we aim to contribute to basic research at the synthesis stage and contribute to related fields through quantitative supply of bioactive compounds after total synthesis is achieved.

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Natural products synthesized by us

Representative Achievements

Asymmetric Total Synthesis of (−)-Maldoxin, a Common Biosynthetic Ancestor of the Chloropupukeananin Family, T. Suzuki, S. Watanabe, M. Uyanik, K. Ishihara, S. Kobayashi, K. Tanino, Org. Lett. 2018, 20, 3919-3922.
Enantioselective Total Synthesis of (+)-Iso-A82775C, a Proposed Biosynthetic Precursor of Chloropupukeananin, T. Suzuki, S. Watanabe, S. Kobayashi, K. Tanino, Org. Lett. 2017, 19, 922-925.
Synthesis of Dibarrelane, a Dibicyclo[2.2.2]octane Hydrocarbon, T. Suzuki, H. Okuyama, A. Takano, S. Suzuki, I. Shimizu, S. Kobayashi, J. Org. Chem. 2014, 79, 2803-2808.
Unexpected Diels-Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of Chloropupukeananin, T. Suzuki, Y. Miyajima, K. Suzuki, K. Iwakiri, M. Koshimizu, G. Hirai, M. Sodeoka, S. Kobayashi, Org. Lett. 2013, 15, 1748-1751.
A Synthetic Study of Atropurpuran: Construction of a Pentacyclic Framework by an Intramolecular Reverse-Electron-Demand Diels-Alder Reaction, T. Suzuki, A. Sasaki, N. Egashira, S. Kobayashi, Angew. Chem., Int. Ed. 2011, 50, 9177-9179.
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Related industries

Fine chemistry, Pharmaceuticals, Agricultural Chemicals, Fragrance
Academic degreePh.D.
Academic background2000  BS, Department of Chemistry, Waseda University
2002  MS, Graduate School of Science and Engineering, Waseda University
2005  Ph.D., Graduate School of Science and Engineering, Waseda University
2003  Research Assosiate, Waseda University
2005  Visiting Research Associatet, Waseda University
2006  Research Associate, The Scripps Research Institute (US)
2007  Research Fellow, Institute of Chemical and Engineering Sciences (Singapore)
2008  Postdoctral Research Associate, Tokyo University of Science
2009  Assistant Professor, Tokyo University of Science
2013  Assistant Professor, Waseda University
2014  Associate Professor, Faculty of Science, Hokkaido University
Affiliated academic societyThe Chemical Society of Japan, The Pharmaceutical Society of Japan, The Society of Synthetic Organic Chemistry, Japan, American Chemical Society
Room addressScience Building 6 #6-01