Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast
Motivated by our recent experiments that demonstrate that the tandemly repeated genes become heterochromatin, here we show a theory of heterochromatin assembly by taking into account the connectivity of these genes along the chromatin in the kinetic equations of small RNA production and histone methylation, which are the key biochemical reactions involved in the heterochromatin assembly. Our theory predicts that……
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Yamamoto, T., Asanuma, T. & Murakami, Y. Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast. Commun Biol 6, 796 (2023).