Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction
Systematic reaction path exploration revealed the entire mechanism of Knowles’s light-promoted catalytic intramolecular hydroamination. Bond formation/cleavage competes with single electron transfer (SET) between the catalyst and substrate. These processes are described by adiabatic processes through transition states in an electronic state and non-radiative transitions through the seam of crossings (SX) between different electronic states. This study determined…..
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Harabuchi, Y., Hayashi, H., Takano, H., Mita, T. and Maeda, S. (2022), Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction. Angew. Chem. Int. Ed.. Accepted Author Manuscript.