Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone and spironolactone
Abstract
The mineralocorticoid receptor (MR) is a nuclear receptor and part of a large and diverse family of transcription factors that also includes receptors for glucocorticoids, progesterone, androgens, and estrogens. The corticosteroid aldosterone is the physiological activator of the MR in humans and other terrestrial vertebrates; however, its activator is not known in cartilaginous fish, the oldest group of extant jawed vertebrates. Here, we analyzed…..
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Article information:
Katsu Y. et al., Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone and spironolactone. Science Signaling, June 4, 2019.
DOI: 10.1126/scisignal.aar2668
