Researcher Information

Masaya Sawamura

Professor

Exploration of Novel Organic Chemistry and Knowledge Creation

Department of Chemistry, Organic and Biological Chemistry

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Theme

Molecular design of organic synthesis catalysts, Development of new chemical reactions, Development of catalytic asymmetric synthesis methods, Theoretical elucidation of chemical reaction mechanisms

FieldOrganic Synthesis, Organometallic Chemistry, Catalysis Chemistry, Asymmetric Synthesis
KeywordOrganic Synthesis, Organometallic Chemistry, Catalysis Chemistry, Asymmetric Synthesis, Phosphines, Ligands, Transition Metal Complexes, Solid Surface, Polymers, Theoretical Calculations, Chirality, Environment-benign Synthesis, Sustainability, Cross-coupling, C–H Activation, Molecular Recognition, Artificial Enzymes, Farmaceutical Compounds, Organic Electronic Materials

Introduction of Research

Our dream is to produce beautiful organic synthesis catalysts that has excellent and versatile functions to achieve ground-breaking new chemical reactions. We are “molecular creators”, who design and develop currently unseen new structures with new functions through combining knowledge of different disciplines such as organic synthesis, coordination chemistry, surface science, computer graphics, and quantum chemical calculations. High-performing organic synthesis catalysts have invariably a beautiful shape and behave beautifully, thereof creating further new knowledge. Thus, organic synthesis catalysts are the greatest subjects for the molecular designers. Formative chemistry and chemical reaction theory, imagination and logic, thinking and doing, intellect and passion, individuality and cooperation; these are mixed together in a romantic and exciting world. This is our playground. In such a world, our team are single-minded to explore new chemistry, exerting our efforts to realize our dream. Notably, the method of our catalyst exploration has a unique feature. That is, we aim at exploring a new field, which has not been seen by anyone but must exist beyond molecules, such as catalysis with chemically functionalized solid surfaces and molecular assemblies. To this end, we are spending our research life with humility and curiosity, and courage and passion to try to learn as much as possible from neighboring research fields such as life sciences and physical chemistry as well as other brand-new interdisciplinary fields. By achieving small objectives of each member and then sharing and accumulating our delights, we are making incremental steps toward realizing our dream.

Representative Achievements

A Polystyrene-Cross-Linking Bisphosphine: Controlled Metal Monochelation and Ligand-Enabled First-Row Transition Metal Catalysis, T. Iwai, T. Harada, H. Shimada, K. Asano and M. Sawamura, ACS Catal. 2017, 7, 1681–1692.
Synthesis of a-Quaternary Formimides and Aldehydes through Umpolung Asymmetric Copper Catalysis with Isocyanides, K. Hojoh, H. Ohmiya and M. Sawamura, J. Am. Chem. Soc. 2017, 139, 2184–2187.
Copper-Catalyzed Enantioselective Allylic Alkylation of Terminal Alkyne Pronucleophiles, A. Harada, Y. Makida, T. Sato, H. Ohmiya and M. Sawamura, J. Am. Chem. Soc. 2014, 136, 13932–13939.
Synthesis of Primary and Secondary Alkylboronates through Site-Selective C(sp3)–H Activation with Silica-Supported Monophosphine–Ir Catalysts,
S. Kawamorita, R. Murakami, T. Iwai and M. Sawamura, J. Am. Chem. Soc. 2013, 135, 2947–2950.
Construction of Eight-Membered Carbocycles via Gold Catalysis with Acetylene-Tethered Silyl Enol Ethers, T. Iwai, H. Okochi, H. Ito and M. Sawamura, Angew. Chem. Int. Ed. 2013, 52, 4239-4242.
Academic degreeDr (Eng)
Academic background1984 B.Eng. Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University
1989 Dr. Eng. Department of Synthetic Chemistry, Graduate School of Engineering, Kyoto University
1989 Assistant Professor, Kyoto University
1993 Researcher, Harvard University (U.S.A., –1994)
1995 Assistant Professor, The University of Tokyo
1996 Lecturer, The University of Tokyo
1997 Associate Professor, The University of Tokyo
2001 Professor, Department of Chemistry, Faculty of Science, Hokkaido University
2016 Hokkaido University Distinguished Professor
2018 Professor, Institute for Chemical Reaction Design and DIscovery (WPI-ICReDD), Hokkaido University
Affiliated academic societyThe Chemical Society of Japan, The Society of Synthetic Organic Chemistry, Japan, Catalysis Society of Japan, Kinka Chemical Society, American Chemical Society
ProjectInstitute for Chemical Reaction Design and DIscovery (WPI-ICReDD), Hokkaido University
Grant-in-Aid for Scientific Research on Innovative Area, MMEXT, Japan
Precise Formation of a Catalysts Having a Specified Field for Use in Extremely Difficult Syubstrate Conversion Reactions
–Precisely Designed Catalysis with Customized Scaffolding–
Room addressFaculty of Science Building 6 6-605