The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary

MURAKAMI Yota

Department of Chemistry

Oct. 12, 2022

Press release (in Japanese)

Abstract
Centromeres of most eukaryotes consist of two distinct chromatin domains: a kinetochore domain, identified by the histone H3 variant, CENP-A, and a heterochromatic domain. How these two domains are separated is unclear. Here, we show that, in Schizosaccharomyces pombe, mutation of the chromatin remodeler RSC induced CENP-A^Cnp1 misloading at pericentromeric heterochromatin, resulting in the mis-assembly of kinetochore proteins and a defect in chromosome segregation. We find that RSC functions at the kinetochore boundary to……

Read the original article on Nucleic Acids Research

Article Information:
Satoru Tsunemine, Hiromi Nakagawa, Yutaka Suzuki, Yota Murakami, The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary, Nucleic Acids Research, 2022;, gkac827, 
DOI: 10.1093/nar/gkac827