Controlling the kinetics of interaction between microtubules and kinesins over a wide temperature range using the deep-sea osmolyte trimethylamine N-oxide

KAKUGO Akira KABIR, Arif Md. Rashedul

Department of Chemistry

Jan. 16, 2020

Press release (in Japanese)

Abstract
Trimethylamine N-oxide is found to be effective in regulating the interaction between microtubules and kinesins over a wide temperature range. The lifetime of the motility of microtubules on kinesins at high temperatures is prolonged using trimethylamine N-oxide. The activation energy of microtubule motility is increased by trimethylamine N-oxide. Prolonged operation at high temperatures decreased the activation energy of MT motility despite the increase in concentration of trimethylamine N-oxide…..

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Article Information:
Tasrina Munmun, Arif Md. Rashedul Kabir, Yukiteru Katsumoto, Kazuki Sadaab, and Akira Kakugo, Controlling the kinetics of interaction between microtubules and kinesins over a wide temperature range using the deep-sea osmolyte trimethylamine N-oxide.
Chem. Commun., 2020, 56, 1187-1190
DOI: 10.1039/C9CC09324A