Stem cells and Reprogramming
Department of Biological Sciences, Reproductive and Developmental Biology
Ikuya Yoshida studies many aspects of epigenetic regulation in mammalian stem cells during development.
|Keyword||Mouse, Stem cell, Heterochromatin, Inactive X chromosome, Reprogramming|
Introduction of Research
Various types of pluripotent stem cell lines have been established from mouse early embryo. These stem cell lines comprise a small number of cells with a distinct state of pluripotency, termed a subpopulation. We use EC (embryonal carcinoma) cells from teratocarcinomas to study how such subpopulations emerged from a clonal EC cell population and how structural changes of heterochromatin occur in the subpopulation cells. Through these investigations, we aim to understand the epigenetic alternations of chromosomal structure and gene expression during mammalian early development.
I am an assistant professor of biological Science at Hokkaido University. When I am not at lab, I enjjoy mountaineering and canoeing
|Academic background||1979-1983 BS., University of Hirosaki, School of science, Biology|
1983-1985 MS, Univesity of Hirosaki, Faculty of Science, Biology
1985-1990 DS, Hokkaido University, Faculty of Science, Zoology
|Affiliated academic society||The molecular biology society of Japan|