Chemogenetic activation of astrocytes modulates sleep/wakefulness states in a brain region-dependent manner
Abstract
[Study objectives]
Astrocytes change their intracellular calcium (Ca2+) concentration during sleep/wakefulness states in mice. Furthermore, the Ca2+ dynamics in astrocytes vary depending on the brain region. However, it remains unclear whether alterations in astrocyte activity can affect sleep/wake states and cortical oscillations in a brain region-dependent manner.
[Methods]
Astrocyte activity was artificially manipulated in mice using chemogenetics. Astrocytes in the hippocampus and pons, which are 2 brain regions previously classified into different clusters based on their Ca2+ dynamics during sleep/wakefulness, were focused on to compare whether there are differences in the effects of astrocytes from different brain regions.
[Results]
The chemogenetic activation of astrocytes in the hippocampus significantly decreased the total time of wakefulness and increased the total time of sleep. This had little effect on cortical oscillations in all sleep/wakefulness states. On the other hand, … …
Read the original article on SLEEP Advances
Article inforamation
Yuta Kurogi, Tomomi Sanagi, Daisuke Ono, Tomomi Tsunematsu, Chemogenetic activation of astrocytes modulates sleep/wakefulness states in a brain region-dependent manner, SLEEP Advances, 2024;, zpae091
DOI: 10.1093/sleepadvances/zpae091
