Teachers

Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) are essential for vertebrate gonadal function, but their expression and function have been revealed to be different among vertebrate lineages. I am interested in experimentally comparing the genomes of various organisms to determine when and how their expression and function changed during evolution, and what genomic changes caused these changes.

References

Fujimori C, Umatani C, Chimura M, Ijiri S, Bando H, Hyodo S, Kanda S. In vitro and in vivo gene transfer in the cloudy catshark Scyliorhinus torazame. Dev Growth Differ. 2022 DOI: 10.1111/dgd.12824

Ogiwara K, Fujimori C, Takahashi T. The PGE2/Ptger4b pathway regulates ovulation by inducing intracellular actin cytoskeleton rearrangement via the Rho/Rock pathway in the granulosa cells of periovulatory follicles in the teleost medaka. Mol Cell Endocrinol. 2023 Jan 15;560:111816. DOI: 10.1016/j.mce.2022.111816

Fujimori C, Ogiwara K, Hagiwara A, Takahashi T. New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes. Mol Cell Endocrinol. 2012 Oct 15;362(1-2):76-84. DOI: 10.1016/j.mce.2012.05.013

Fujimori C, Ogiwara K, Hagiwara A, Rajapakse S, Kimura A, Takahashi T. Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: possible involvement in ovulation. Mol Cell Endocrinol. 2011 Jan 30;332(1-2):67-77. DOI: 10.1016/j.mce.2010.09.015