To unravel mysteries in the birth of animals

KOTANI, TomoyaAssociate Professor

Reproductive and Developmental Biology
Molecular and Developmental Biology
To elucidate cellular and mollecular mechanisms of vertebrate oogenesis and embryogenesis
Developmental biology
Maternal factor

A multicellular organism begins with a single cell, the fertilized egg, and undergoes differentiation, morphogenesis and pattern formation to become an embryo. All cellular functions and patterning decisions that occur prior to the activation of the zygotic genome depend on maternal factors deposited in the egg during oogenesis, which become active after fertilization. At present, however, little is known about the molecular mechanisms underlying oogenesis and early developmental processes.

We successfully isolated the maternal insertional mutation using a transposon system in zebrafish and identified the gene responsible for the mutant phenotype. Our aim is to find novel molecular mechanisms of gametogenesis and early developmental processes by isolating and analyzing such mutations.


Faculty of Science
Department of Biological Sciences
Reproductive and Developmental Biology

Grad School

Graduate School of Life Science
Division of Life Science
Biosystems Science Course

Contact Information

Faculty of Science, Building #5 5-1109
Email: tkotani [atmark] sci.hokudai.ac.jp

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