SATO Yuta

SATO Yuta
Specially Appointed Assistant Professor

Investigation of Epigenetic Eraser

Department of Chemistry, Organic and Biological Chemistry

Theme	Mechanism of heterochromatin formation by epigenetic erasers and its universality
Field	Cell biology, Molecular biology, Epigenetics, Bioimaging
Keyword	Heterochromatin, Epigenetics, Cell morphology, Cell motility

Introduction of Research

Transcriptional gene switching is regulated by chemical modifications on histone proteins and/or DNA, that is, epigenetic marks. Not only gene-coding regions, higher chromatin structures such as pericentric heterochromatin are also regulated by the modifications. We now focus on Epigenetic erasers. So far, we have been studying epigenetics/chromatin using S. pombe; we started to use mammalian cells to investigate the importance of epigenetic erasers in broader life science.

Representative Achievements

Isoform-dependent subcellular localization of LMTK1A and LMTK1B, and their roles in axon outgrowth and spine formation., Wei R., Sugiyama A., Sato Y., Nozumi M., Nishino H., Takahashi M., Saito T., Ando K., Fukuda M., Tomomura M., Igarashi M., and Hisanaga SI., J. Biochem., 2020, 168 (1) 23-32

DOI: 10.1093/jb/mvaa019

Nonmuscle myosin IIA and IIB differently suppress microtubule growth to stabilize cell morphology., Sato Y., Kamijo K., Tsutsumi M., Murakami Y. and Takahashi M., J. Biochem., 2020, 167 (1), 25-39.

DOI: 10.1093/jb/mvz082

Semi-retentive cytoskeletal fractionation (SERCYF): A novel method for the biochemical analysis of the organization of microtubule and actin cytoskeleton networks. S,ato Y., Murakami Y. and Takahashi M. Biochem. Biophys. Res. Commun., 2017, 488, 614–620.

DOI: 10.1016/j.bbrc.2017.05.083

Academic degree	Ph. D
Self Introduction	I was born and grown in Sapporo. I was a student of Hokkaido University (2008-2019). After working at Niigata university for 1 year, I came back here. The main project was cytoskeleton-associated cell biology; now, I am challenging epigenetics. Cats.
Academic background	2012 B.S., School of Science, Hokkaido University 2014 M.S., Graduate school of Chemical Sciences and Engineering, Hokkaido University 2019 Ph.D., Graduate school of Chemical Sciences and Engineering, Hokkaido University 2019 Project-assistant professor, Department of Neurochemistry and Molecular Cell biology, Niigata University 2020- Project-assistant professor, Faculty of Science, Hokkaido University
Affiliated academic society	Japan Society for Cell Biology, The Japanese Biochemical Society
Room address	Science Building 7 7-206